The Sesto Elemento is equipped with a 6-speed semi-automatic transmission with paddle shift and all wheel drive system, mated to a 5.2 litre V10 engine borrowed from the Gallardo, generating 578 PS (425 kW; 570 hp) and 540 N·m (400 lbf·ft) of torque. The chassis, body, drive shaft and suspension components are made of carbon fibre, reducing the overall weight to a mere 999 kilograms (2,202 lb), a weight comparable to subcompact cars.

Air is released through 10 distinctive hexagonal holes in the engine cover, while two intakes funnel cool air into the mid-mounted engine compartment. The Sesto Elemento's high power combined with low overall weight translate to a power-to-weight ratio of 0.57 hp/kg (0.26 hp/lb) (with a weight-to-power ratio of 1.75 kg/hp and 3.85 lb/hp). Lamborghini claims a 0–100 km/h (0–62 mph) acceleration time of just 2.5 seconds. Lamborghini sources said that "...they will sell it in very small numbers, in 2013."

The Sesto Elemento's interior is generally bare with few vehicle comforts such as air-conditioning and car stereo. The seats are made of foam and stuck onto the chassis of the vehicle, reducing weight and production costs.